Project Assistant in Medicine (Sweden) Deadline: April 11, 2019

Lund University

Application Deadline

April 11, 2019

Career Commencement

May 01, 2019

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The Offer

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 40 000 students and 7 400 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Faculty of Medicine is a part of Lund University and is responsible for education and research within medicine and healthcare. The academic programs are closely linked with the healthcare system and are firmly anchored in the faculty’s strong research tradition. Research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.
 
The position of Research Assistant offered is for a project on programed neurons, patients with Alzheimer’s disease (AD). The focus of the project is to study induced human neurons (iN) from patients with Alzheimer’s disease. AD is a common neurodegenerative disease, which leads to progressive brain atrophy and cognitive decline. Ageing and genetic factors are the two key risk factors for AD. There is still no cure or disease-modifying treatments, which is partly because the basic mechanisms of the disease are unclear. Studies on clinically relevant disease models are key to move the field forward. Therefore iN from patients with AD are used iN are directly converted from fibroblasts, and may (in contrast to neurons generated from iPSCs) preserve age at the cellular level. This opens for a possibility to understand how age-related changes in key molecular pathways lead to AD.

The project assistant will work on projects on iN cells in AD. One of the research aims is to correlate secretory pathway phenotypes with DNA-methylation-based epigenetic age of iN from donors with AD. The work may include cell culture of iN cells, biochemical analyses of DNA methylation and cellular AD biomarkers as well as light-microscopy imaging of iNs.

The successful candidate will join a multidisciplinary research team, spanning from experimental lab scientists to clinical researchers. The research in the field of cellular disease models is expanding and a successful assistant will be encouraged to apply for a PhD student position in the team. Ultimately, the goal is to facilitate the development of effective treatments for AD.

 

Eligibility/ Requirements

Requirements include:

  • Completed second-cycle degree, completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or largely equivalent knowledge acquired in some other way, in Sweden or abroad.
  • Excellent written communication skills.

Other qualifications considered as merits:

Experience from cell biology work, experimental neuroscience, and/or other projects on neurodegenerative diseases.

Application Process

Login and apply online here with all supporting documents. Reference no. PA2019/729.

More information here.

If you have questions, contact Niklas Mattsson, Associate senior lecturer, email: niklas.mattsson@med.lu.se

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